Exposome Data Interpretation Resource (EDIR)

The inter-chemical correlations detected in human specimens can be interpreted in several contexts. 

Exogenous compounds : 

1. Chemical group - eg phthalates, PFAS

2. Exposure source - eg plasticizers, diet, drug-combinations, cigarette smoke

3. Transformation products -  eg caffeine metabolites

4. Hazard effects -  eg mitochondrial damage biomarkers

Endogenous compounds : 

1. Pathway - eg TCA cycle

2. Reactants - eg xanthine and hypoxanthine

3. Chemical class - eg acyl-carnitines

4. Master regulators  - eg PPAR

5. Dietary intake: eg amino acid supplements, red-meat intake, or whole-wheat pasta

6. Gut microbiota ecology : eg secondary bile acids

Note : In untargeted chemical analyses, chemicals forms during the sample analysis will also correlate with each other, for example the ESI adducts for a chemical. 

EDIR catalogues these relationships among chemicals which are then linked with the inter-chemical correlations curated in the CCDB database.